Figure 5.

Extracellular Hsp90 signals through the LRP-1 receptor to promote reepithelialization during wound healing. Akt is essential for extracellular Hsp90α signaling to promote cell migration and wound healing. How LRP-1 mediates Hsp90α signaling to other three pathways and the function of these pathways in Hsp90α-induced wound healing remain to be investigated. The question marks indicate that intermediate activators of the pathways listed remain unclear. To see this illustration in color, the reader is referred to the web version of this article at www.liebertpub.com/wound