Figure 6.

Newly restandardized acute and diabetic pig wound healing models. (A–C) 2.0×2.0 cm full-thickness wounds were created on the same side of the pigs (n=3), 2.0 cm apart between wounds, and were compared either between the top and the bottom wounds (A) or between the middle and rear wounds (B) or between wounds made at the similar spots, but on the opposite sides of the pig (C). Quantitations (% of healing) were made based on triplicate wounds in each pig and are shown below each of the images. (D, E) A schematic presentation of nine 2.0×2.0 cm (in normal pigs) or 1.5×1.5 cm (in diabetic pigs) full-thickness wounds created on each side of the pig, 2.0 cm apart between wounds. Comparison between treatment and control should be made between two wounds at the similar spots, but on the opposite sides of the pig, as indicated by same color squares. (F, G) Based on the above design, real wounds were created on the two sides of pigs. Treatments versus controls are indicated. Taken from O'Brien et al.¹⁹ with permission.