Table 4. Relative abundances of key genera responding to rotavirus (RV) infection and dietary treatment identified by redundancy analysis and univariate statistics (PROC MIXED).
Genus |
Non-infected |
RV-infected |
P-value |
||||||
---|---|---|---|---|---|---|---|---|---|
FF | HMO | PRE | FF | HMO | PRE | Diet | Infection | Diet × infection | |
Anaerotruncus | 0.26±0.07 | 0.26±0.03 | 0.15±0.03 | 0.07±0.02 | 0.09±0.04 | 0.15±0.05 | 0.73 | 0.02 | 0.04 |
Bacteroides | 26.19±4.12 | 21.60±3.81 | 20.65±4.97 | 47.95±8.76 | 45.7±8.61 | 42.15±7.33 | 0.69 | <0.0001 | 0.85 |
Blautia | 5.47±1.14 | 11.2±1.95 | 5.71±1.46 | 4.6±1.58 | 4.25±1.72 | 3.69±0.96 | 0.56 | 0.01 | 0.44 |
Clostridium IV | 0.35±0.1 | 0.51±0.2 | 0.14±0.05 | 0.14±0.05 | 0.05±0.03 | 0.07±0.03 | 0.38 | <0.0001 | 0.53 |
Clostridium XlVa | 3.69±1.22 | 1.78±0.16 | 5.06±1.13 | 1.91±0.75 | 1.21±0.52 | 2.38±1.05 | 0.03 | 0.0033 | 0.64 |
Clostridium XVIII | 0.03±0.02 | 0.12±0.05 | 0.01±0.01 | 0.19±0.18 | 0.64±0.5 | 0.06±0.03 | 0.05 | 0.07 | 0.55 |
Faecalibacterium | 0.14±0.04 | 0.32±0.12 | 0.56±0.31 | 1.46±0.67 | 1.62±0.89 | 8.47±5.41 | 0.0045 | 0.0002 | 0.32 |
Lactococcus | 0.2±0.07 | 0.16±0.05 | 0.04±0.03 | 0.04±0.02 | 0.01±0.01 | 0.01±0.01 | 0.05 | 0.00 | 0.25 |
Parabacteroides | 9.33±2.93 | 11.02±3.86 | 10.00±3.86 | 2.84±0.98 | 3.54±1.55 | 3.73±1.69 | 0.88 | 0.0014 | 0.66 |
Streptococcus | 2.99±0.93 | 2.22±0.53 | 1.06±0.41 | 0.35±0.07 | 0.32±0.06 | 0.5±0.26 | 0.05 | <0.0001 | 0.03 |
Turicibacter | 0.56±0.22 | 0.54±0.22 | 2.68±1.19 | 0.14±0.08 | 0.02±0.01 | 0.13±0.06 | 0.05 | 0.0004 | 0.20 |
Unclassified Clostridiaceae 1 | 0.03±0.01 | 0.19±0.1 | 0.02±0.01 | 0.01±0.01 | 0.04±0.03 | 0.02±0.01 | 0.05 | 0.28 | 0.19 |
Unclassified Lachnospiraceae | 6.93±0.97 | 15.69±2.39 | 7.28±1.18 | 10.67±2.95 | 19.89±2.91 | 9.68±1.21 | <0.0001 | 0.01 | 1.00 |
unclassified Peptostreptococcaceae | 0.08±0.02 | 0.11±0.04 | 0.14±0.03 | 0.05±0.02 | 0.02±0.01 | 0.04±0.02 | 0.82 | 0.01 | 0.66 |
Unclassified Ruminococcaceae | 13.41±2.93 | 4.66±0.77 | 7.16±1.53 | 5.59±1.25 | 2.92±0.68 | 3.62±0.86 | 0.0002 | 0.003 | 0.68 |
Abbreviations: FF, formula fed; HMO, formula supplemented with human milk oligosaccharides (HMO) (4 g l−1); PRE, formula supplemented with short-chain galactooligosaccharides and long-chain fructooligosaccharides (4 g l−1).
Values are means±s.e.m. (n=7–13 per group).