Table 3. Multivariable analyses between complement proteins and extent of calcification.

	CACa			ACa
C3
	β(SE)b	95% CI	P-value	β(SE)b	95% CI	P-value
Unadjusted	0.57(0.15)	(0.28, 0.86)	<0.001	0.63(0.23)	(0.17, 1.09)	0.007
Model 1c	0.55(0.17)	(0.22, 0.88)	<0.001	0.70(0.26)	(0.18, 1.23)	0.009
Model 2c	0.47(0.18)	(0.11, 0.84)	0.011	0.56(0.28)	(-0.001,1.13)	0.051
Model 2 + TATd	0.30(0.18)	(-0.06, 0.67)	0.103	0.14(0.31)	(-0.48, 0.76)	0.654
Model 2 + PVATd	0.21(0.18)	(-0.14, 0.56)	0.238	0.27(0.29)	(-0.31, 0.85)	0.356
C4
	β(SE)b	95% CI	P-value	β(SE)b	95% CI	P-value
Unadjusted	0.16(0.16)	(-0.15, 0.46)	0.320	0.04(0.24)	(-0.43, 0.52)	0.854
Model 1c	0.14(0.16)	(-0.18, 0.46)	0.378	0.05(0.25)	(-0.45, 0.55)	0.853
Model 2c	0.13(0.17)	(-0.21, 0.46)	0.445	-0.001(0.26)	(-0.51, 0.51)	0.997
Model 2 + TATd	0.08(0.16)	(-0.23, 0.39)	0.595	-0.27(0.26)	(-0.79, 0.25)	0.309
Model 2 + PVATd	0.02(0.15)	(-0.28, 0.32)	0.878	-0.12(0.25)	(-0.61, 0.37)	0.618

^alog(CAC+1), log(AC+1)

^bβ per standard deviation (SD) ; SD of C3= 33.28 mg/dl, SD of C4= 8.77 mg/dl

^cModel 1: Adjusted for age, race and menopausal status; Model 2: Model 1+ LDL-C

^dlog transformed