. Author manuscript; available in PMC: 2016 Apr 1.

Published in final edited form as: Nucleosides Nucleotides. 1996;15(1-3):693–717. doi: 10.1080/07328319608002416

Table 2.

Antagonism of A₁ receptor-mediated inhibition of adenylyl cyclase in rat adipocycte membranes.^a

Compound^b	K_B ± SEM (μM)
4	600
18	17.1 ± 3.6
24	10.8 ± 3.0
26	600
61	600
64	46.7 ± 11.9
67	3.94 ± 0.79
77	81
86	1.36 ± 0.48
95	12.7 ± 2.95

Calculated from shift in dose-response curve to R-PIA (see Figure 3), using the Schild equation⁸ (n=3–5, or for single determination).

Compound 71 (50 μM) caused a slight shift of the R-PIA dose-respose curve to the left. Compound 91 (50 μM) antagonized the effects of R-PIA only weakly, thus a K_B could not be determined.