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. 2016 Apr;26(4):417–426. doi: 10.1101/gr.203216.115

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© 2016 Li et al.; Published by Cold Spring Harbor Laboratory Press

This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genome.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.

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Figure 5. — Transmission characteristics of heteroplasmies for novel versus polymorphic heteroplasmies. (A) Proportion of minor alleles observed in mothers that disappear entirely, decrease in frequency, or increase in frequency in the offspring for novel versus polymorphic heteroplasmies. (B) Distribution across genic regions of all heteroplasmies involving novel versus polymorphic heteroplasmies. (C) Distribution across genic regions for novel heteroplasmies that disappeared in the offspring [Novel(D)] compared to polymorphic heteroplasmies that disappeared in the offspring [Polymorphic(D)]. The MT-RNR1 and MT-RNR2 genes and the tRNA genes are overrepresented in the novel heteroplasmies.