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There are two molecular components to the “synaptic” mark (Martin et al. 1997a,b). (Top) Activation of the cyclic adenosine-3-monophosphate (cAMP)-dependent protein kinase is required to have any capture at all. (Middle, bottom) Local protein synthesis is necessary for the maintenance of long-term facilitation (LTF) beyond 24 h. (From Casadio et al. 1999; with permission, from Elsevier © 1999.) 5-HT, Serotonin; EPSP, excitatory postsynaptic potential.
