Table 1.
Ligands for α–β integrin heterodimers
| Integrin | Representative ligands |
|---|---|
| α1β1 | Collagen, laminin |
| α2β1 | Collagen, laminin |
| α3β1 | Laminin, fibronectin |
| α4β1 | VCAM-1, fibronectin, thrombospondin |
| α4β7 | VCAM-1, fibronectin, MAdCAM-1 |
| α5β1 | Fibronectin, neural adhesion molecule L1 |
| α6β1 | Laminin |
| α6β4 | Laminin |
| α7β1 | Laminin |
| α8β1 | Osteopontin, fibronectin, vitronectin, tenascin |
| α9β1 | Tenascin, osteopontin, VCAM-1 |
| α10β1 | Collagen |
| α11β1 | Collagen |
| αEβ1 | E-cadherin |
| αLβ2 | ICAM-1, ICAM-2, ICAM-3 |
| αMβ2 | ICAM-1, ICAM-2, ICAM-4, fibrinogen |
| αXβ2 | ICAM-1, fibrinogen |
| αDβ2 | ICAM-3, VCAM-1 |
| αIIbβ3 | Fibrinogen, fibronectin, vitronectin, thrombospondin, von Willebrand factor |
| αVβ3 | Vitronectin, fibronectin, fibrinogen, osteopontin |
| αVβ5 | Vitronectin |
| αVβ6 | Vitronectin, fibronectin |
| αVβ8 | Fibronectin, laminin, collagen, vitronectin |
| α6β4 | Laminin |
| α4β7 | VCAM-1, fibronectin |