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. 2015 Dec 1;24(2):240–250. doi: 10.1038/mt.2015.176

Figure 1.

Figure 1

Experimental protocol. (a) Schematic detailing the construct of the human cDNA containing vector. (b) Timeline of the administration of the cDNA containing vectors (either rat or human) to mice and the experimental protocols followed over the 4-week period. (R1+R2) = rAAV6 vectors containing either the rat R1 or R2 cDNAs driven by the human cTnT455 regulatory cassette (RC). (RRM1.RRM2), rAAV6-human (RRM1.RRM2)cTnT455 vector in which the RRM1 cDNA is 5' of the RRM2 cDNA and separated by a self-cleaving peptide sequence; RRM2.RRM1, treatment with an analogous vector with the RRM2 cDNA 5' of the RRM1 cDNA; (RRM1+RRM2), RRM1, and RRM2 cDNA containing vector.