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. 2015 Dec 1;24(2):240–250. doi: 10.1038/mt.2015.176

Figure 3.

Figure 3

Isolated perfused hearts from adult mice with overexpressed R1 and R2 subunits exhibit increased cardiac function. Cardiac function was assessed in isolated perfused mouse hearts 4 weeks post-rAAV6 injection. (a) Left ventricular (LV) developed pressure (LV Dev P, the difference of LV systolic and LV diastolic pressures). (b) Heart rate (HR). (c) Rate pressure product (the product of LVDevP and HR). (d) Positive rate of pressure change calculated by the first derivative of the ascending LV pressure wave (+dP/dt), used as an index of the rate of pressure development. (e) Negative rate of pressure change calculated by the first derivative of the descending LV pressure wave (−dP/dt), used as an index of the rate of ventricular relaxation. (f) Coronary flow estimated by collecting the perfusate effluent over a 2-minute period. *P < 0.05 versus CON. CON, control; RR, heart from mouse treated with rAAV6-ratRrm1cTnT455 and rAAV6-ratRrm2cTnT455; n = 4 each group.