Figure 8.

Treatment of DBA/2J mice with rAAV2/8.mEpoR76E at 5 months preserves RGC axon histology at 10 months. (a–c) Representative bright field micrographs of optic nerves from (a) 3-month-old mice (n = 11) or from 10-month-old mice treated with (b) rAAV2/8.eGFP (n = 15) or (c) rAAV2/8.mEpoR76E (n = 11). Degenerative axons are indicated by arrows. Bar = 25 µm. (d–f) Scatter plots of quantification of (d) percent degenerating axons, (e) live axons, and (f) total axons, circle indicates cohort of highly degenerated optic nerves that were not present in the other groups. rAAV, recombinant adeno-associated virus