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. 2016 Feb 9;24(2):318–330. doi: 10.1038/mt.2015.211

Figure 3.

Figure 3

Intravenous mesenchymal stem cells and parathyroid hormone combination therapy regenerates vertebral defects in osteoporotic rats: micro-computerized tomography analysis. (a) Rats with identical vertebral bone voids were treated with mesenchymal stem cells (MSCs) or saline and with low-dosage parathyroid hormone (ldPTH), high-dosage parathyroid hormone (hdPTH), or vehicle. The animals were imaged using micro-computed tomography 1 day and 2, 4, 8, and 12 weeks postoperatively. A representative vertebral defect at various time points for each group is depicted in each panel as a frontal 3D image (left side) with new bone formation in the void highlighted in red, a sagittal 2D image (upper right), and an axial 2D image (lower right). (b and c) Quantitative analysis of bone formation in the voids was performed and bone volume density and apparent density were calculated. Data are shown as mean + SEM (control: n = 7; MSCs: n = 9; ldPTH: n = 8; hdPTH: n = 9; MSCs+ldPTH: n = 8; MSCs+hdPTH: n = 9). Repeated measures two-way ANOVA with Bonferroni correction for multiple comparisons was preformed; *P < 0.05, **P < 0.01, and ***P < 0.001.