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. 2016 Jan 5;24(2):306–317. doi: 10.1038/mt.2015.219

Figure 3.

Figure 3

SPECT/CT imaging reveals changes in density and distribution of intratumoral infection centers in animals with altered perfusion states during VSV-Δ51-NIS administration. (a) Coronal SPECT/CT planar image through center of representative MPC11 tumor-bearing BALB/C mouse days 1, 2, and 3 following administration of i.v. VSV-Δ51-NIS during exercise (top) or during anesthesia (bottom). (b) Quantification of radioactive Tc99m concentration above background per cubic centimeter of tumor in MPC11 tumor bearing BALB/C mice days 1, 2, and 3 following administration of i.v. saline negative control (gray, n = 1),VSV-Δ51-NIS during exercise (green, n = 5), and VSV-Δ51-NIS during anesthesia (orange, n = 5). There is a significant increase in radionuclide uptake in animals exercised during administration of VSV-Δ51-NIS relative to VSV-Δ51-NIS under anesthesia on d1 and d2 (d1 P = 0.0012, d2 P = 0.0064, t-test).