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. 2015 Jun 30;23(8):1285–1297. doi: 10.1038/mt.2015.105

Figure 4.

Figure 4

Improved ex vivo muscle function in mdx mice treated with rMsGal-1. Mice were weighed each week starting at 10 days of age continuing till 10 weeks with no significant changes in weight (a). Isolated skeletal muscles were excised and wet mass was recorded (b,c,f). Isometric tetanic contractions were performed in vitro in isolated extensor digitorum longus (EDL) muscles from wild type (WT) and mdx PBS and rMsGal-1-treated mice at 10 weeks of age. Isometric tetanic specific force is improved in the EDL (d) and soleus (g) of mdx mice treated with rMsGal-1. Force frequency analysis of EDL (e) and soleus (h) and expressed in specific force. Data represent averages and error bars represent standard deviation of the mean. Statistics were calculated using analysis of variance with a Bonferroni correction (*P < 0.05, **P < 0.01, ***P < 0.001). #P < 0.05 Statistically significant difference from WT to mdx mice treated with rMsGal-1. $P < 0.05 Statistically significant difference from WT to mdx mice treated with PBS.