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. 2015 Jun 30;23(9):1434–1443. doi: 10.1038/mt.2015.92

Figure 5.

Figure 5

ACE2 attenuated NADPH oxidase subunit translocation from the membrane to the cytosol. rAAV2/8-ACE2 therapy markedly reduced protein level of NADPH p67phox protein subunit in the membrane (a and c) but had no effect on cytosolic subunit levels (b and d) in the BDL, CCl4, and MCD models, suggesting rAAV2/8-ACE2 inhibited membrane translocation of p67phox subunit. Each bar represents the mean ± SEM profile from n >10 mice per treatment group. *P < 0.0001, #P < 0.01, ^P < 0.05, and ns = nonsignificant were calculated by one-way analysis of variance with Tukey comparison test.