Figure 6.

ACE2 inhibited hepatic oxidative stress via reduction of lipid peroxidation. Oxidative stress in the BDL, CCl₄, and MCD models was evaluated morphometric analysis of (a and b) liver sections stained with 4-hydroxynonenal, which showed a significant reduction of hepatic oxidative stress by rAAV2/8-ACE2 therapy. Each bar represents the mean ± SEM profile from n > 10 mice per treatment group. *P < 0.0001, ^#P < 0.01, and ^P < 0.05 were calculated by one-way analysis of variance with Tukey comparison test.