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ACE2 significantly reduced hepatic vasoconstriction. Perfusion pressure in the liver was evaluated by in situ perfused mouse liver experiment. rAAV2/8-ACE2 gene therapy reduced methoxamine induced vasoconstriction in the livers of BDL mice, thus improving intrahepatic vascular resistance to portal inflow. Each symbol represents the mean ± SEM profile from n = 4 to 5 per treatment group. ^P < 0.05 was calculated by Student's two-tailed, unpaired t-test.
