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. 2015 Sep 1;23(11):1712–1721. doi: 10.1038/mt.2015.142

Figure 8.

Figure 8

CD74 suppresses Aβ production from cultivated human neurons. (a,b) Human neurons (1 × 105 cells/well in 48-well plates) were transduced with AAV-tTA at 0.5 × 109 vg combined with AAV-TRE-GFP or CD74 (0.5 × 109 vg) for 3 days. Neuron culture media were subjected to Aβ40 (a) or Aβ42 (b) enzyme-linked immunosorbent assay tests. Bars represent mean ± standard error of the mean. * or ** denotes P < 0.05 or 0.01 versus control or plus AAV-TRE-GFP as determined by one-way analysis of variance, Newman-Keuls post hoc test. AAV, adeno-associated virus; GFP, green fluorescent protein; TRE, tet-response element; tTA, tetracycline transactivator.