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. Author manuscript; available in PMC: 2016 Apr 1.
Published in final edited form as: Exp Oncol. 2012 Oct;34(3):176–184.

Fig. 3.

Fig. 3

Multifunctional roles of c-FLIP on various signaling pathways. As discussed in the text, in addition to its functional role in inhibiting apoptosis by binding to procaspases-8 and -10 and inhibiting their activation, c-FLIP activates various anti-apoptotic and cell survival signaling pathways, leading to proliferation and cell survival