Table 2.
Summary of RNA-Seq studies in SCZ cohorts.
| SAMPLE SIZE* | TISSUE | PLATFORMS† | CANDIDATE GENES | REFERENCE |
|---|---|---|---|---|
| 18 (9S, 9C) | Superior temporal gyrus | Illumina GA | DCLK1; TP53, PRKACA, STAT3, SP1, DRD2, DDR3, HTR2A | Wu et al. (2012)43; Huang et al. (2014)44 |
| 22 (22S) | Blood | Illumina GA | ADAMTS2, CD177, CNTNAP3, ENTPD2, RFX2, UNC45B | Crespo-Facorro et al. (2015)45 |
| 29 (14S, 15C) | Hippocampus | Illumina GA | IFITM1, IFITM2, IFITM3, APOL1, ADORA2A, IGFBP4, CD163 | Hwang et al. (2013)46 |
| 40 (20S, 20C) | Dorsolateral prefrontal cortex | SOLiD | IL-6, IL-8, IL-1β, SERPINA3 | Fillman et al. (2013)47; Catts et al. (2014)48 |
| 6 (3S, 3C) | Blood | Illumina GA | S100A8, TYROBP | Xu et al. (2012)49 |
| 76 (36S, 40C) | Blood | Illumina GA | ADAMTS2, CSMD1, EHF, RFX2, GRIK3, LPL, S100B, SNCA, SYN2, TUBB2A, SELENBP1, CSMD1 | Sainz et al. (2013)50 |
| 79 (17S, 16B, 17M, 40C) | Dentate gyrus (Hippocampus) | SOLiD | miR-182 | Kohen et al. (2014)53 |
| 144 (55S, 34B, 55C) | Prefrontal cortex | SOLiD | FKBP5, PTGES3, BAG1 | Sinclair et al. (2013)54 |
| 82 (31S, 25B, 26C) | Cingulate cortex | Illumina GA and HiSeq | FER, FGF13, IDH1, DYNLT3, TRPV1, CBFA2T2,MTA2, IGSF11, NAP1L5 | Zhao et al. (2015)55 |
| 22 (11B, 11C) | Dorsolateral prefrontal cortex | Illumina GA and HiSeq | ABCG2, SRSF5, RFX4 | Akula et al. (2015)56 |
| 59 (30M, 29C) | Dorsolateral prefrontal cortex | Illumina MiSeq | SAT1 | Pantazatos et al. (2015)57 |
Notes:
*
Schizophrenia (S); bipolar disorder (B); recurrent major depressive disorder (M); and healthy control (C).
†
Illumina Genome Analyzer (GA), HiSeq, and MiSeq sequencers and Applied Biosystems SOLiD™ sequencer.