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. 2016 Apr 1;10(4):e0004592. doi: 10.1371/journal.pntd.0004592

Fig 2. Increase in IL-17 and IL-21 bearing CD3+CD4+ T cells in patients undergoing leprosy reactions.

Fig 2

Flowcytometry analysis of antigen stimulated PBMC from one each of representative patient with RR, BT, ENL, and LL leprosy (see Materials and Methods). Dot plot shows percentage of CD3+ gated CD4+ cells with intracellular IL-17A (Figs A, D), IL-17F (Figs B, E) and IL-21 (Figs C, F) in BT, RR and LL, ENL subjects. Scattergram (Mean % ± SD of cells) confirms the significant increase in percentage of Th17 cells in RR, ENL compared to BT, LL patients respectively for IL-17A, IL-17F cytokines as indicated by p values. IL-21+ cells were increased only in ENL. p< 0.05 was considered statistically significant (two tailed Mann-Whitney). (), parenthesis shows number of subjects tested. Abbreviations as in Fig 1.