Table 2. Effects of TLS on the levels of MDA and the activities of SOD and T-AOC in the hippocampus and cerebral cortex.
Group | Hippocampus | Cerebral cortex | ||||
---|---|---|---|---|---|---|
MDA (nmol/mg protein) | SOD (U/mg protein) | T-AOC (U/μg protein) | MDA (nmol/mg protein) | SOD (U/mg protein) | T-AOC (U/μg protein) | |
Control | 16.63 ± 2.12 ## | 19.26 ± 0.62 ## | 6.06 ± 1.23 # | 18.13 ± 2.52 ## | 24.03 ± 1.10 ## | 51.36 ± 5.76 ## |
Sham | 11.47 ± 2.27 | 26.36 ± 1.17 | 7.95 ± 0.93 | 11.41 ± 1.15 | 34.18 ± 1.28 | 67.38 ± 3.73 |
Donepezil | 13.52 ± 3.13 | 23.68 ± 1.29 | 7.80 ± 1.36 * | 14.76 ± 2.01 | 35.90 ± 4.50 ** | 66.54 ± 3.21 * |
TLS 50 mg/kg | 14.06 ± 3.07 | 26.13 ± 1.83 * | 7.84 ± 0.55 * | 15.11 ± 0.79 | 30.02 ± 1.79 | 64.32 ± 4.11 * |
TLS 200 mg/kg | 12.08 ± 2.67 * | 28.07 ± 2.65 ** | 8.41 ± 0.38 ** | 12.83 ± 1.87 * | 32.84 ± 2.36 ** | 71.71 ± 1.72 ** |
Values indicated mean ± S.E.M. and were analyzed by one-way analysis of variance (ANOVA) followed by Tukey's multiple comparison test (n = 8).
#p < 0.05 and
##p < 0.01 compared with the sham group
*p < 0.05 and
**p < 0.01 compared with the control group.