Table 2.

Crude event rates by quintile of visit-to-visit variability of systolic blood pressure defined as the coefficient of variation or average real variability among 114,900 adults with chronic kidney disease stage 3–4.

	Visit-to-Visit Variability in Blood Pressure Using Coefficient of Variation
	1st Quintile	2nd Quintile	3rd Quintile	4th Quintile	5th Quintile
Death
Events, N	721	878	992	1194	1329
Rate per 100 p-y (95% CI)	3.23 (2.99, 3.47)	3.95 (3.69, 4.21)	4.48 (4.20, 4.76)	5.42 (5.11, 5.73)	6.05 (5.73, 6.38)
End-stage renal disease
Events, N	50	90	133	162	147
Rate per 100 p-y (95% CI)	0.22 (0.16, 0.29)	0.41 (0.32, 0.49)	0.60 (0.50, 0.70)	0.74 (0.62, 0.85)	0.67 (0.56, 0.78)
Acute coronary syndrome
Events, N	194	214	249	292	340
Rate per 100 p-y (95% CI)	0.87 (0.75, 0.99)	0.96 (0.83, 1.09)	1.12 (0.98, 1.26)	1.33 (1.17, 1.48)	1.55 (1.38, 1.71)
Heart failure
Events, N	270	423	520	660	655
Rate per 100 p-y (95% CI)	1.21 (1.07, 1.35)	1.90 (1.72, 2.09)	2.35 (2.15, 2.55)	3.00 (2.77, 3.22)	2.98 (2.76, 3.21)
Ischemic Stroke
Events, N	138	133	144	193	209
Rate per 100 p-y (95% CI)	0.62 (0.52, 0.72)	0.60 (0.50, 0.70)	0.65 (0.54, 0.76)	0.88 (0.75, 1.00)	0.95 (0.82, 1.08)
Hemorrhagic Stroke
Events, N	96	146	187	185	213
Rate per 100 p-y (95% CI)	0.43 (0.34, 0.52)	0.66 (0.55, 0.76)	0.84 (0.72, 0.97)	0.84 (0.72, 0.96)	0.97 (0.84, 1.10)

	Visit-to-Visit Variability in Blood Pressure Using Average Real Variability
	1st Quintile	2nd Quintile	3rd Quintile	4th Quintile	5th Quintile
Death
Events, N	761	1009	1070	1108	1166
Rate per 100 p-y (95% CI)	3.45 (3.21–3.70)	4.54 (4.26–4.82)	5.08 (4.77–5.38)	4.98 (4.69–5.28)	5.05 (4.76–5.34)
End-stage renal disease
Events, N	42	99	129	154	158
Rate per 100 p-y (95% CI)	0.19 (0.13–0.25)	0.45 (0.36–0.53)	0.61 (0.51–0.72)	0.69 (0.58–0.80)	0.69 (0.58–0.79)
Acute coronary syndrome
Events, N	191	227	239	295	337
Rate per 100 p-y (95% CI)	0.87 (0.74–0.99)	1.02 (0.89–1.15)	1.13 (0.99–1.28)	1.33 (1.18–1.48)	1.46 (1.30–1.62)
Heart failure
Events, N	307	485	534	602	600
Rate per 100 p-y (95% CI)	1.39 (1.24–1.55)	2.18 (1.99–2.38)	2.53 (2.32–2.75)	2.71 (2.49–2.92)	2.60 (2.39–2.81)
Ischemic Stroke
Events, N	133	143	142	173	226
Rate per 100 p-y (95% CI)	0.60 (0.50–0.71)	0.64 (0.54–0.75)	0.67 (0.56–0.78)	0.78 (0.66–0.89)	0.98 (0.85–1.11)
Hemorrhagic Stroke
Events, N	130	105	213	174	205
Rate per 100 p-y (95% CI)	0.59 (0.49–0.69)	0.47 (0.38–0.56)	1.01 (0.87–1.15)	0.78 (0.67–0.90)	0.89 (0.77–1.01)