Table 2.
Baseline outcomes compared across SAI slope exposure cohorts and stratified by race
| African American SAI Post-Transplant Slope | Non-African American SAI Post-Transplant Slope | |||||
|---|---|---|---|---|---|---|
| Variables | Increase (n=74) | No Change (n=461) | Decrease (n=43) | Increase (n=89) | No Change (n=362) | Decrease (n=66) |
| Recipient Characteristics | ||||||
| Mean Age (±SD) | 52±13 | 51±13 | 50±12 | 50±13 | 53±15 | 50±14 |
| Female Gender | 32% | 45% | 39% | 37% | 41% | 36% |
| History of Diabetes* | 36% | 41% | 35% | 15% | 30% | 28% |
| History of Hypertension | 97% | 95% | 94% | 90% | 89% | 87% |
| History of Heart Disease | 16% | 15% | 15% | 15% | 24% | 19% |
| Preemptive | 14% | 9% | 13% | 38% | 35% | 32% |
| Mean Years on Dialysis (±SD) | 3.3±2.5 | 3.7±3.0 | 3.1±3.0 | 1.4±1.9 | 1.8±2.1 | 1.8±2.3 |
| Previous Kidney Transplant^ | 8% | 5% | 15% | 17% | 12% | 12% |
| Donor Characteristics | ||||||
| Deceased Donor*^ | 91% | 93% | 80% | 64% | 74% | 82% |
| Mean Age (±SD) | 36±16 | 35±16 | 35±13 | 36±14 | 37±15 | 36±16 |
| AA Race | 45% | 33% | 38% | 30% | 18% | 19% |
| Extended Criteria Donor | 12% | 12% | 8% | 15% | 16% | 13% |
| Transplant Characteristics | ||||||
| Cytolytic Induction* | 45% | 47% | 41% | 44% | 38% | 54% |
| Mean PRA (±SD) | 15±29 | 19±30 | 14±25 | 16±30 | 17±31 | 16±30 |
| PRA >20%^ | 21% | 32% | 20% | 20% | 25% | 25% |
| PRA >80% | 9% | 9% | 7% | 9% | 10% | 9% |
| Mean HLA MM (±SD) | 4.4±1.5 | 4.6±1.3 | 4.6±1.1 | 3.4±1.6 | 3.8±1.7 | 3.8±1.6 |
| Mean Cold Time, hrs (±SD)* | 19±9 | 18±8 | 16±11 | 13±11 | 15±10 | 17±9 |
| Mean Warm Time, min (±SD) | 37±8 | 36±8 | 36±12 | 35±10 | 36±9 | 36±7 |
| Delayed Graft Function* | 12% | 18% | 13% | 1% | 10% | 10% |
^
p<0.05 for comparison within African Americans
*
p<0.05 for comparison within non-African Americans