Table 1.
Baseline characteristics of PAH at the time of diagnosis from different registries
| Registry | NIH [12] | French [10] | US [9] | REVEAL [11] | UK/Ireland [7] | ASPIRE# [39] | COMPERA [8] | Swiss [13] |
| Year | 1987 | 2006 | 2007 | 2010 | 2012 | 2012 | 2013 | 2015 |
| Subjects n | 187 | 674 | 578 | 2525 | 482 | 175 | 587 | 171 |
| Age years | 36±15 | 50±15 | 48 ± 14 | 50.1±14.4 | 50.1±17.1 | 55±16 | 71±16 | 60±15 |
| Women % | 63 | 65.3 | 77 | 55.6 | 69.9 | 67 | 60.3 | 56 |
| mPAP mmHg | 60±18 | 55±15 | 52±14 | 50.7±13.6 | 54.1±13.9 | 53±13 | 44±12 | 46±12 |
| PAWP mmHg | ¶ | 8±3 | 10±4 | 9.1±3.5 | 9.2±3.5 | 10±3 | 10±3 | 12±7 |
| RAP mmHg | 9.7±6 | 8±5 | 11±7 | 9.3±5.6 | 10.1±6.0 | 11±6 | 8±5 | 9±8 |
| CI L min−1 m−2 | 2.27±0.9 | 2.50±0.8 | 2.3±0.9 | 2.4±0.8 | 2.1±0.7 | 2.3±0.8 | 2.2±0.7 | 2.6±0.8 |
| PVRi WU·m2 | 26±14 | 20.5±10.2 | 21.1±12.5 | 23.1±10.3 | ||||
| PVR WU | 12.5±7.3 | 12.8±6.3 | 12.0±5.8 | 9.6±5.5 | 8.5±5.2 |
Data are expressed as mean±sd or % unless otherwise stated. mPAP: mean pulmonary artery pressure; PAWP: pulmonary artery wedge pressure; RAP: right atrial pressure; CI: cardiac index; PVRi: pulmonary vascular resistance index; PVR: pulmonary vascular resistance. #: Patients diagnosed with idiopathic PAH. ¶: PAWP was 8.69±3.9 in males and 7.94±3.7 in females. Data from ref [7–13, 39].