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. 2015 Dec 9;21(1):924–936. doi: 10.2119/molmed.2015.00193

Figure 3.

Figure 3

Intraperitoneal transfer of M(IL-4)s does not require host lymphocytes to protect against DNBS colitis. The M(IL-4) transfer model was repeated in RAG1 KO mice (lacking T and B cells) to determine whether host lymphocytes were essential for the anticolitic effect. The data show that wild-type M(IL-4) were still able to attenuate (A) colon shortening, and only mice treated with DNBS alone were significantly different from naive controls in terms of macroscopic damage, MPO activity, and (B) histological damage. Experiments were repeated twice: naive control (n = 5), DNBS (n = 10), DNBS + M(IL-4) (n = 10). p < 0.05: †compared with naive control; #compared with DNBS + M(IL-4). Bar represents 50 μm; M, muscularis; L, lumen. Data are represented as the mean ± SEM.