Table 1.
Baseline characteristics of the 20 included patients, intended to treat
| Unit | Mean (±SD) | |
|---|---|---|
| Age | Years | 66.0 (±6.5) |
| NIV settings | ||
| BPM | per minute | 12.9 (±2.5) |
| IPAPmin | cm H2O | 13.8 (±3.7) |
| IPAPmax | cm H2O | 17.5 (±3.3) |
| EPAP | cm H2O | 5.4 (±0.7) |
| Ti | 1.3 (±0.2) | |
| Vt | mL | 554.3 (±136.7) |
| PC/AVAPS | n | 10/10 |
| Lung function | ||
| FEV1 | L | 0.67 (±0.44) |
| FEV1 | % pred | 27.8 (±16.2) |
| FVC | L | 1.77 (±0.66) |
| MRC | Median (IQR) | 4 (±1) |
| Pack years | 44.6 (±18.8) | |
| BMI | kg/m2 | 23.7 (±6.8) |
| SpO2 | % | 93.4 (±3.1) |
| Oxygen supply | L | 2.4 (±3.2) |
| Arterial gas values confirming AHRF | ||
| pH | 7.26 (±0.07) | |
| Pa,CO2 | kPa | 11.3 (±1.8) |
| Pa,O2 | kPa | 8.5 (±1.7) |
| stBE | mmol/L | 11.2 (±5.4) |
| Medication and therapy | ||
| LAMA | n (%) | 17 (85) |
| LABA | n (%) | 18 (90) |
| ICS | n (%) | 16 (80) |
| OCS | n (%) | 4 (20) |
| Theophylline | n (%) | 4 (20) |
| Rehabilitation | n (%) | 11 (55) |
| LTOT | n (%) | 18 (90) |
NIV: non-invasive positive pressure ventilation; BPM: breaths per minute; IPAP: inspiratory positive airway pressure; EPAP: expiratory positive airway pressure; Ti: inspiratory time; Vt: ventilated volume per minute; PC: pressure control; AVAPS: average volume assured pressure ventilation; FEV1: forced expiratory volume in one second; FVC: forced vital capacity; MRC: Medical Research Council dyspnea score; IQR: interquartile range; BMI: body mass index; SpO2: peripheral oxygen saturation; AHRF: acute hypercapnic respiratory failure; Pa,CO2: arterial carbon dioxide tension; Pa,O2: arterial oxygen tension; stBE: standard base-excess concentration in arterial blood; LAMA: long-acting muscarinic antagonists; LABA: long-acting β2 agonists; ICS: inhaled corticosteroids; OCS: oral corticosteroids; LTOT: long-term oxygen therapy.