Table 2.
Per protocol analysis on the 16 patients who were still alive 1 year after LTNIV initiation
| Per protocol: variables at LTNIV initiation vs. after 1 year with LTNIV, n=16 | ||||
|---|---|---|---|---|
| Prior to LTNIV | After 1 year with LTNIV | |||
| Unit | Mean (±SD) | Mean (±SD) | p | |
| FEV1 | L | 0.73 (±0.48) | 0.71 (±0.44) | 0.94 |
| FEV1 | % pred | 30.7 (±16.7) | 29.9 (±16.9) | 0.93 |
| FVC | L | 1.77 (±0.66) | 1.68 (±0.64) | 0.78 |
| LTOT | n (%) | 14 (87.5) | 11 (68.8) | 0.20 |
| pH | 7.40 (±0.04) | 7.42 (±0.03) | 0.17 | |
| Pa,CO2 | kPa | 7.6 (±1.7) | 6.7 (±1.4) | 0.11 |
| Pa,O2 | kPa | 9.0 (±2.1) | 9.0 (±1.8) | 0.98 |
| stBE | mmol/L | 7.4 (±5.5) | 7.0 (±5.5) | 0.76 |
| AHRF admissions | n/year | 2.4 (±0.6) | 0.4 (±0.6) | <0.0001 |
| Admissions | n/year | 5.2 (±3.5) | 1.9 (±3.2) | 0.0092 |
| Admission days | n/year | 42.6 (±27.3) | 11.9 (±22.3) | 0.0015 |
LTNIV: long-term non-invasive positive pressure ventilation; FEV1: forced expiratory volume in one second; FVC: forced vital capacity; LTOT: long-term oxygen therapy; Pa,CO2: arterial carbon dioxide tension; Pa,O2: arterial oxygen tension; stBE: standard base-excess concentration in arterial blood; AHRF: acute hypercapnic respiratory failure.