Table 2.
Area under the curve of biochemical and blood pressure variables at Postprandial 1 and 2
| Postprandial 1 (day 1) | Postprandial 2 (day 28) | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| AUC | Control (n=12) | Cocoa (n=11) | pa | Control (n=12) | Cocoa (n=11) | pb | pc | pd | pe |
| Glucose (mg·h/dL) | 286.9 (43.5) | 314.8 (29.1) | ns | 292.9 (37.3) | 314.4 (33.6) | ns | ns | ns | ns |
| Insulin (µU·h/dL)f | 75.9 (60.4) | 97.6 (73.8) | ns | 68.6 (50.3) | 77.0 (48.5) | ns | ns | ns | ns |
| Total-c (mg·h/dL) | 664.5 (120.2) | 714.1 (194.7) | ns | 551.0 (88.1) | 577.2 (138.8) | ns | <0.001 | 0.001 | ns |
| HDL-c (mg·h/dL) | 161.7 (44.0) | 154.0 (25.4) | ns | 141.0 (25.6) | 134.3 (23.8) | ns | 0.011 | 0.001 | ns |
| SBP (mmHg·h) | 338.0 (31.0) | 376.0 (46.6) | 0.007 | 317.0 (28.8) | 340.0 (36.6) | ns | 0.015 | 0.001 | 0.016 |
| DBP (mmHg·h) | 226.0 (19.8) | 240.0 (22.8) | ns | 205.0 (17.9) | 220.0 (21.7) | ns | <0.001 | 0.001 | ns |
Data presented as unadjusted mean (SD). Comparisons between both groups were performed with an independent t test or Mann–Whitney U test and comparisons between Postprandial 1 and 2 were analysed by paired student t test or Wilcoxon test, depending on the normality of the variables.
ANCOVA univariate analyses adjusted for fasting value of each assessed variable, baseline weight, and ▵weight differently combined were performed.
p<0.05 was considered as significant.
AUC control vs. AUC cocoa group in Postprandial 1, adjusted for baseline value of the assessed variable in Postprandial 1 and baseline weight.
AUC control vs. AUC cocoa group at Postprandial 2, adjusted for baseline value of the assessed variable at Postprandial 2 and Δweight.
AUC control group in the Postprandial 1 vs. AUC control group in the Postprandial 2.
AUC cocoa group in the Postprandial 1 vs. AUC cocoa group in the Postprandial 2.
Difference in the change (Postprandial 1 and Postprandial 2) in AUC between control and cocoa groups, adjusted for Δbaseline value of the variable (baseline value at Postprandial 2-fasting value at Postprandial 1) and Δweight.
No-normally distributed variables.
AUC: area under the curve; DBP: diastolic blood pressure; HDL-c: high-density lipoprotein cholesterol; ns: not significant; SBP: systolic blood pressure; Total-c: total cholesterol; Δweight: weight change.