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. 2016 Apr 1;18:77. doi: 10.1186/s13075-016-0979-0

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© Gonzalo-Gil et al. 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — Embryonic stem cell-derived mesenchymal stromal cells (hESC-MSC) migrate to the inguinal lymph nodes (ILN) and induce expression of murine indoleamine 2,3 dioxygenase (IDO1). a Expression of HLA-C transcripts in the ILN of mice with collagen-induced arthritis (CIA) treated with hESC-MSC compared to the phosphate-buffered saline (PBS)-treated group. b Expression of murine IDO1 (mIDO1) in the ILN of mice with CIA treated with vehicle (PBS) or with hESC-MSC and showing evidence of migration (HLA⁺) or not (HLA^–). Data show values from individual mice and the mean of the experimental groups. Statistical differences were analyzed by Kruskall-Wallis analysis of variance and Dunn’s multiple comparisons test. *P < 0.05; **P < 0.01