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. 2016 Apr 1;20:9. doi: 10.1186/s40824-016-0056-4

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© Choi et al. 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 5 — Biological safety of HCD matrix containing S-EGF and S-bFGF, in vivo. The matrix was applied on the wound of STZ-induced diabetic mice with following groups; defect control, HCD control, HCD + S-EGF 0.3 μg/cm², HCD + S-EGF 1 μg/cm², HCD + S-EGF 2.5 μg/cm², HCD + S-bFGF 0.3 μg/cm², HCD + S-bFGF 1 μg/cm², and HCD + S-bFGF 2.5 μg/cm². The macroscopic representative images were taken on day 0 and 7 (a) and quantitative analysis of wound area is measured (b). *p < 0.05, **p < 0.01