Table 3.
Circulating inflammatory mediators in animals at baseline and after sea water drowning
| Baseline | 15 min | 120 min | 240 min | |
|---|---|---|---|---|
| IL-8 | ||||
| Control | 81.83 ± 34.22 | 106.8 ± 17* | 161.1 ± 48.6* | 174.3 ± 59.7* |
| CVVH | 87.67 ± 15.77 | 111.4 ± 8.3* | 91.01 ± 17.5# | 85.37 ± 23.6# |
| IL-6 | ||||
| Control | 219.4 ± 58.5 | 323.3 ± 96.1* | 339.5 ± 106.5* | 365.6 ± 119.5* |
| CVVH | 212.9 ± 33.0 | 378.5 ± 57.7* | 249.9 ± 48.2 | 221.4 ± 27.8# |
| TNF-α | ||||
| Control | 53.82 ± 16.81 | 79.53 ± 9.48* | 76.17 ± 8.11* | 89.78 ± 10.5* |
| CVVH | 50.34 ± 15.10 | 83.21 ± 8.95* | 63.52 ± 11.3# | 61.43 ± 17.6# |
| Endothelin | ||||
| Control | 0.08 ± 0.05 | N/A | N/A | 0.19 ± 0.11* |
| CVVH | 0.09 ± 0.04 | N/A | N/A | 0.10 ± 0.04# |
Plasma IL-8, IL-6, TNF-α, and endothelin levels were from animals before and after involuntary intratracheal sea water infusion. All animals received mechanical ventilation after sea water infusion and then were randomly divided into control and CRRT group *p < 0.05, vs, the same group of animals before infusion (baseline); #p < 0.05,vs, animals in control group at the same time point