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. 2016 Apr 1;8:35. doi: 10.1186/s13148-016-0199-0

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© Kristiansen et al. 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — ROC curve for detection of hypermethylated RASSF1A. Data plot of the sensitivity and 100 % specificity. Serum DNA was isolated from serum from 24 patients with metastatic breast cancer and 24 age-matched healthy control individuals. The DNA was incubated with either the methylation-resistant restriction enzymes HpaII or BstUI and thereafter PCR amplified with six different primer designs (primer ID # 32, 40, 50, 54, 63, and 66, as explained in Table 2) covering different regions of the promoter and exon 1 of RASSF1A