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. Author manuscript; available in PMC: 2016 Sep 1.
Published in final edited form as: Clin Sci (Lond). 2016 Mar 1;130(5):317–335. doi: 10.1042/CS20150087

Figure 2. Effects of Nox-derived ROS on redox-sensitive longevity signalling in the vessel wall.

Figure 2

Summary of the effects of hypertension, atherosclerosis and PAH on age-related redox-sensitive signalling pathways linked to the different vascular cells comprising the vessel wall (intima: endothelial cells; media: VSMCs; adventitia: fibroblasts/myofibroblasts) as a consequence of Nox-derived ROS. Arrows depict either increased or decreased protein expression or signalling pathway activation. A question mark (?) depicts a potential effect wherein more conclusive evidence is required to fully support the observations in the literature.