Table 2.
Spermine affinities of kainate receptors
| Receptor | Mean | SEM | n | |
|---|---|---|---|---|
| GluK2 | K d (0 mV) (μm) | 5.8 | 0.3 | 5 |
| h (mV) | −16.0 | 0.5 | ||
| k (mV) | 20.4 | 1.0 | ||
| GluK2/GluK5 | K d (0 mV) (μm) | 119 | 30 | 5 |
| h (mV) | −25.9 | 3.8 | ||
| k (mV) | 69.7 | 36.0 | ||
| GluK2+Neto1 | K d (0 mV) (μm) | 71 | 13 | 6 |
| h (mV) | −24.0 | 1.8 | ||
| k (mV) | 43.3 | 4.3 | ||
| GluK2+Neto2 | K d (0 mV) (μm) | 39 | 2 | 7 |
| h (mV) | −18.5 | 1.1 | ||
| k (mV) | 48.6 | 5.3 | ||
| GluK2/GluK5(P599G) | K d (0 mV) (μm) | 19 | 2 | 4 |
| h (mV) | −32.3 | 3.8 | ||
| k (mV) | 41.4 | 4.7 | ||
| GluK2 (300 μm l‐Glu) | K d (0 mV) (μm) | 21 | 6 | 3 |
| h (mV) | −24.2 | 1.9 | ||
| k (mV) | 56.2 | 14.1 | ||
| GluK2/GluK5 | K d (0 mV) (μm) | 170 | 33 | 3 |
| (300 μm l‐Glu) | h (mV) | −51.4 | 20.0 | |
| k (mV) | 107.7 | 47.2 | ||
| GluK2/GluK5 | K d (0 mV) (μm) | 81 | 40 | 3 |
| (1 mm AMPA) | h (mV) | −73.4 | 27.7 | |
| k (mV) | 56.8 | 22.9 |
Affinities were obtained using responses evoked by 1 ms applications of 1 mm l‐Glu in 150 mm NaCl external solution. Values for ‘h’ and ‘k’ indicate the voltage dependency.