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. 2016 Feb 27;594(7):1931–1952. doi: 10.1113/JP271361

Figure 4. Running‐ and swimming‐based 10‐month training programmes induced neuroprotection of motor neuron subpopulations in type 3 SMA‐like mice .

Figure 4

A, immunodetection of ChAT‐positive motor neurons in the lumbar spinal cord (L1–L5) of sedentary control mice (left) compared to sedentary (middle left), running‐trained (middle right) and swimming‐trained (right) type 3 SMA‐like mice at 12 months of age (scale bar: 50 μm). B–D, quantitative analysis of the number of total, medial and lateral motor neurons per ventral horn (B) and of the absolute number (C) or proportion (D) of motor neurons in small (> 300 μm²), intermediate (300–600 μm²) and large (< 600 μm²) range of cell body area in the spinal cord of sedentary control mice compared to sedentary, running‐trained (Run) and swimming‐trained (Swim) type 3 SMA‐like mice at 12 months of age (n = 8 for each group). Data are represented as means ± SD (*P < 0.05).