Table 2.
Comparison of running and swimming benefits in type 3 SMA‐like mice
| Physical exercise improvements | Run SMA | Swim SMA |
|---|---|---|
| Grip strength preservation | +++ | +++ |
| Muscle resistance to low intensity test | + | +++ |
| Muscle resistance to high intensity test | + | +++ |
| Motor neuron protection | ++ | +++ |
| Medial motor neurons | ++ | +++ |
| Large motor neurons | + | +++ |
| Chodl + neurons | − | +++ |
| ERRβ+ motor neurons | +++ | − |
| Preservation of NMJ shape | +++ | +++ |
| Muscle hypertrophy (increased CSA) | +++ | +++ |
| Intermediate myofibres | +++ | ++ |
| Large myofibres | + | +++ |
| Neuromuscular excitability | +++ | +++ |
Comparison of the 10‐month running and swimming exercises efficiency of the analysed parameters (motor capacity and motor unit) which have been improved by physical exercise in the type 3 SMA‐like mice. The level of efficiency to improve each parameter is represented by ‘–’ for no efficiency, + for low efficiency (under sedentary control levels), ++ for moderate efficiency and +++ for high efficiency (equal or superior to sedentary control levels). The grey highlighting indicate which exercise induced the better effect on a considered parameter.