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Cell divisions and errors in spermatogenesis in the course of aging. A continuous series of DNA replication and mitosis take place during spermatogenesis. Primordial germ cells undergo about 30 mitotic divisions during intrauterine development. After puberty, DNA replication and mitosis continue and 20–25 mitotic divisions occur each year during adulthood. Errors during DNA replication are the primary source of point mutations in spermatozoa
