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YMRS (A) and HDRS (B) total scores for healthy comparison subjects (HC, n=28), asymptomatic adolescents with a biological parent with bipolar I disorder (‘high-risk’, HR; n=31), adolescents with a biological parent with bipolar I disorder and MDD or depressive disorder-NOS (‘ultra high-risk’, UHR; n=36), and first-episode bipolar patients (BP, n=35). Values are group mean ± S.E.M. ***P≤0.0001 vs. HC, ##P≤0.01, ###P≤0.001 vs. HR, ++P≤0.01, +++P≤0.001 vs. UHR.
