Percentage of subjects in the healthy comparison (HC), high-risk (HR), ultra high-risk (UHR), and first-episode bipolar (BP) groups with an omega-3 index (EPA+DHA) of ≤4.0% (A) or a AA/EPA+DHA ratio ≤4.6 (median-split)(B). *P≤0.05, **P≤0.01, ***P≤0.0001 vs. HC, #P≤0.05, ###P≤0.001 vs. HR, +++P≤0.001 vs. UHR (Chi-Square test).