Table 1.
Association analysis of APOE genotypes and alleles with longevity and lipid profile.
| Type | Frequency (centenarians n=438, controls n=515) | LDL level | |||||
|---|---|---|---|---|---|---|---|
| Centenarians (%) |
Controls (%) |
OR (95% CI) | p-value | Type | The rest | p-value | |
| ε2 | 86 (9.82) | 62 (6.02) | 1.70 (1.21–2.39) | 0.003* | 91.7+/−5.26 | 109+/−1.51 | 0.002* |
| ε3 | 732 (83.6) | 875 (85) | 0.90 (0.70–1.15) | 0.412 | 108+/−1.57 | 102+/−3.67 | 0.11 |
| ε4 | 58 (6.62) | 93 (9.03) | 0.71 (0.51–1.00) | 0.061 | 112+/−5.09 | 107+/−1.52 | 0.41 |
| ε2/ε2 | 4 (0.91) | 2 (0.39) | 2.36 (0.43–13.0) | 0.422 | 74.5+/−21.6 | 108+/−2.07 | 0.13 |
| ε2/ε3 | 72 (16.4) | 52 (10.1) | 1.75 (1.20–2.57) | 0.005* | 93.9+/−5.75 | 109+/−2.19 | 0.01* |
| ε2/ε4 | 6 (1.37) | 6 (1.17) | 1.18 (0.38–3.68) | 0.780 | 94+/−27.8 | 108+/−2.08 | 0.63 |
| ε3/ε3 | 309 (70.5) | 371 (72) | 0.93 (0.70–1.23) | 0.616 | 109+/−2.4 | 103+/−3.86 | 0.15 |
| ε3/ε4 | 42 (9.59) | 81 (15.7) | 0.57 (0.38–0.85) | 0.005* | 113+/−5.63 | 107+/−2.2 | 0.30 |
| ε4/ε4 | 5 (1.14) | 3 (0.58) | 1.97 (0.47–8.29) | 0.481 | 109+/−19.7 | 107+/−2.09 | 0.92 |
Bold numerals with asterisk indicate p-value < 0.05.