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. Author manuscript; available in PMC: 2017 Apr 1.
Published in final edited form as: Clin Cancer Res. 2015 Nov 23;22(7):1674–1686. doi: 10.1158/1078-0432.CCR-14-2890

Figure 4.

Figure 4

NSCLC cell lines with mesenchymal gene expression patterns are more sensitive to PLK1 inhibition than are those with epithelial gene expression patterns. E-cadherin mRNA (CDH1; A) and protein (B) expression levels were significantly higher in PLK1 inhibition-resistant cell lines than in sensitive ones. C, EMT scores for PLK1 inhibition-sensitive and -resistant cell lines determined using a published signature (17). Data on KRAS-mutant cell lines are shown in red. D, E-cadherin and vimentin protein expression levels in 2 representative cell lines according to Western blotting. PLK1 inhibition-sensitive and -resistant cell lines are indicated in green and red, respectively.