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. Author manuscript; available in PMC: 2017 Apr 1.
Published in final edited form as: Clin Cancer Res. 2015 Nov 23;22(7):1674–1686. doi: 10.1158/1078-0432.CCR-14-2890

Figure 5.

Figure 5

Mesenchymal cells are more sensitive to PLK1 inhibition than are epithelial cells in isogenic human NSCLC models. A, forced expression of miR-200 led to increased E-cadherin expression and decreased vimentin expression according to Western blotting and to volasertib resistance according to an MTT assay. Induction of a mesenchymal phenotype by ZEB1 expression (B) or 5 ng/mL transforming growth factor-β (C) led to volasertib sensitivity and increased volasertib-induced apoptosis. *P ≤ 0.05 compared with a control or as indicated. PLK1 inhibition-sensitive and -resistant cell lines are indicated in green and red, respectively.