Table 1.
Age distribution, preoperative CA 125 levels, FIGO staging, and p53 expression in different primary ovarian neoplasms
| Histological diagnosis | No. of cases (Column %) | Age at diagnosis (year) | Preoperative CA 125 level (U/ml) | FIGO staging (Row %) | p53 Expression (Row %) |
|---|---|---|---|---|---|
| All ovarian tumors | 86 (100.0) | 40.1 ± 14.0 Median: 39 Min: 12 Max: 79 |
178.0 ± 340.2 Median: 56.0 Min: 11.3 Max: 1890.0 |
I: 64 (74.4) II: 10 (11.6) III: 6 (7.0) IV: 6 (7.0) |
0: 42 (48.8) 1 + : 14 (16.3) 2 + : 16 (18.6) 3 + : 5 (5.8) 4 + : 4 (4.7) 5 + : 5 (5.8) |
| I. Benign Surface epithelial-stromal tumors (BSEST) | 31 (36.0) | 38.1 ± 6.9 Median: 39 Min: 22 Max: 49 |
60.6 ± 54.1 Median: 32.0 Min: 12.6 Max: 212.0 |
I: 31 (100.0) II: 0 (0.0) III: 0 (0.0) IV: 0 (0.0) | 0: 16 (51.6) 1 + : 10 (32.3) 2 + : 5 (16.1) 3 + : 0 (0.0) 4 + : 0 (0.0) 5 + : 0 (0.0) |
| A. Serous cystadenoma | 19 (22.1) | 41.2 ± 4.8 Median: 41 Min: 32 Max: 49 |
72.6 ± 62.9 Median: 45.0 Min: 12.6 Max: 212.0 |
I: 19 (100.0) | 0:7 (36.8) 1 + : 7 (36.8) 2 + : 5 (26.3) |
| B. Mucinous cystadenoma | 11 (12.8) | 32.6 ± 6.9 Median: 34 Min: 22 Max: 42 |
43.7 ± 29.9 Median: 31.0 Min: 21.3 Max: 108.0 |
I: 11 (100.0) | 0: 8 (72.7) 1 + : 3 (27.3) |
| C. Brenner tumor* | 1 (1.2) | 39 | 18.2 | I: 1 (100.0) | 0: 1 (100.0) |
| II. Borderline Surface epithelial-stromal tumors (BOT) | 5 (5.8) | 48.6 ± 9.9 Median: 43 Min: 39 Max: 62 |
104.4 ± 143.1 Median: 53.0 Min: 22.3 Max: 359.5 |
I: 2 (40.0) II: 2 (40.0) III: 1 (20.0) IV: 0 (0.0) | 0: 0 (0.0) 1 + : 2 (40.0) 2 + : 2 (40.0) 3 + : 1 (20.0) 4 + : 0 (0.0) 5 + : 0 (0.0) |
| A. Borderline serous tumor* | 2 (2.3) | 56 & 62 | 31.0 & 359.0 | I: 1 (50.0) III: 1 (50.0) | 2 + : 1 (50.0) 3 + : 1 (50.0) |
| B. Borderline mucinous tumor | 3 (3.5) | 41.7 ± 2.3 Min: 39 Max: 43 |
44.0 ± 19.2 Min: 22.4 Max: 57.0 |
I: 1 (33.3) II: 2 (66.7) | 1 + : 2 (66.7) 2 + : 1(33.3) |
| III. Malignant Surface epithelial-stromal tumors (MSEST) | 19 (22.1) | 59.3 ± 8.7 Median: 59 Min: 46 Max: 79 |
586.3 ± 551.8 Median: 346.0 Min: 24.0 Max: 1890.0 |
I: 2 (10.5) II: 6 (31.6) III: 5 (26.3) IV: 6 (31.6) | 0: 1 (5.3) 1 + : 1 (5.3) 2 + : 4 (21.1) 3 + : 4 (21.1) 4 + : 4 (21.1) 5 + : 5 (26.3) |
| A. Serous adenocarcinoma | 14 (16.3) | 61.7 ± 8.3 Median: 60 Min: 48 Max: 79 |
765.1 ± 538.2 Median: 560.0 Min: 190.0 Max: 1890.0 |
II: 4 (28.6) III: 4 (28.6) IV: 6 (42.9) | 2 + : 2 (14.3) 3 + : 3 (21.4) 4 + : 4 (28.6) 5 + : 5 (35.7) |
| B. Mucinous adenocarcinoma* | 2 (2.3) | 46 & 49 | 24.1 & 58.0 | I: 2 (100.0) | 0: 1 (50.0) 3 + : 1 (50.0) |
| C. Endometrioid adenocarcinoma* | 2 (2.3) | 49 & 59 | 89.0 & 180.0 | II: 1 (50.0) III: 1 (50.0) | 1 + : 1 (50.0) 2 + : 1 (50.0) |
| D. Clear cell adenocarcinoma* | 1 (1.2) | 58 | 76.6 | II: 1 (100.0) | 2 + : 1 (100.0) |
| IV. Germ cell tumors (GCT) | 27 (31.4) | 27.0 ± 6.4 Median: 27 Min: 12 Max: 39 |
60.5 ± 64.5 Median: 43.0 Min: 11.4 Max: 340.6 |
I: 25 (92.6) II: 2 (7.4) III: 0 (0.0) IV: 0 (0.0) | 0: 21 (77.8) 1 + : 1 (3.7) 2 + : 5 (18.5) 3 + : 0 (0.0) 4 + : 0 (0.0) 5 + : 0 (0.0) |
| A. Mature cystic teratoma | 17 (19.8) | 28.6 ± 6.8 Median: 31 Min: 12 Max: 39 |
40.5 ± 25.3 Median: 32.0 Min: 11.4 Max: 102.0 |
I: 17 (100.0) | 0: 17 (100.0) |
| B. Immature teratoma* | 1 (1.2) | 16 | 56.0 | I: 1 (100.0) | 2 + : 1 (100.0) |
| C. Dysgerminoma | 3 (3.5) | 24.7 ± 3.8 Min: 22 Max: 29 |
72.0 ± 42.0 Min: 24.0 Max: 102.0 |
I: 2 (66.7) II: 1 (33.3) | 0: 1 (33.3) 1 + : 1 (33.3) 2 + : 1 (33.3) |
| D. Yolk sac tumor | 3 (3.5) | 25.3 ± 2.9 Min: 22 Max: 27 |
34.3 ± 18.7 Min: 23.2 Max: 56.0 |
I: 3 (100.0) | 0: 3 (100.0) |
| E. Embryonal carcinoma* | 1 (1.2) | 19 | 340.6 | I: 1 (100.0) | 2 + : 1 (100.0) |
| F. Mixed germ cell tumor* | 2 (2.3) | 26 & 31 | 102.0 &128.0 | I: 1 (50.0) II: 1 (50.0) | 2 + : 2 (100.0) |
| V. Sex cord-stromal tumors (SCT) | 4 (4.7) | 43.0 ± 8.5; Min: 31 Max: 49 |
33.5 ± 13.1 Min: 16.8 Max: 45.5 |
I: 4 (100.0) II: 0 (0.0) III: 0 (0.0) IV: 0 (0.0) | 0: 4 (100.0) 1 + : 0 (0.0) 2 + : 0 (0.0) 3 + : 0 (0.0) 4 + : 0 (0.0) 5 + : 0 (0.0) |
| A. Adult granulosa cell tumor* | 2 (2.3) | 48 & 49 | 31.3 & 45.0 | I: 2 (100.0) | 0: 2 (100.0) |
| B. Sertoli-Leydig cell tumor* | 1 (1.2) | 31 | 42.0 | I: 1 (100.0) | 0: 1 (100.0) |
| C. Fibroma* | 1 (1.2) | 43 | 16.3 | I: 1 (100.0) | 0: 1 (100.0) |
Median calculated for sample size ≥5; Figures in parentheses are column or row percentages
* Exact values are written in case of small number (<3) of observations