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. 2016 Mar 16;7(4):281–290. doi: 10.1007/s13238-016-0257-6

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© The Author(s) 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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A schematic to summarize the role of SIRT6 in oxidative stress-induced neuronal damage. SIRT6 enhances neuronal cell death under oxidative stress via induction of autophagy mediated by attenuation of AKT signaling