. 2016 Apr 2;15:35. doi: 10.1186/s12937-016-0147-z

Table 4.

Effects of sequence, time, and intervention on gastrointestinal symptoms

Outcome	Effect^a,b		Estimate (log odds ratio)^c	SE	95 % confidence limit		P-value^d
					Lower	Upper
Bloating	Sequence 1 vs. 2		0.0522	0.8788	−1.6701	1.7745	0.9526
	Sequence 1	W1 vs. BL	1.7527	0.6363	0.5055	2.9999	0.0059
		W2 vs. BL	1.6511	0.6742	0.3297	2.9724	0.0143
		W3 vs. BL	−0.051	0.5686	−1.1655	1.0635	0.9285
		W4 vs. BL	−0.496	0.8014	−2.0667	1.0748	0.536
		W5 vs. BL	−0.051	0.7783	−1.5765	1.4745	0.9477
		W6 vs. BL	−1.2279	1.2429	−3.6639	1.2082	0.3232
	Sequence 2	W1 vs. BL	0.3289	0.5601	−0.7689	1.4267	0.5571
		W2 vs. BL	0.2792	0.5768	−0.8513	1.4097	0.6283
		W3 vs. BL	−0.0479	0.5305	−1.0876	0.9918	0.928
		W4 vs. BL	−0.0479	0.5305	−1.0876	0.9918	0.928
		W5 vs. BL	1.9572	0.6713	0.6415	3.2729	0.0036
		W6 vs. BL	1.7308	0.6743	0.4092	3.0525	0.0103
Abdominal pain	Sequence 1 vs. 2		0.5028	0.9654	−1.3893	2.3949	0.6025
	Sequence 1	W1 vs. BL	0.6221	0.6176	−0.5884	1.8325	0.3138
		W2 vs. BL	1.0837	0.5145	0.0754	2.092	0.0352
		W3 vs. BL	0.3417	0.5903	−0.8152	1.4987	0.5626
		W4 vs. BL	−0.4568	0.4501	−1.339	0.4255	0.3103
		W5 vs. BL	0	0.5458	−1.0698	1.0698	1
		W6 vs. BL	−0.4568	0.4501	−1.339	0.4255	0.3103
	Sequence 2	W1 vs. BL	−0.735	1.3002	−3.2834	1.8134	0.5719
		W2 vs. BL	0	1.0937	−2.1436	2.1436	1
		W3 vs. BL	0	1.0937	−2.1436	2.1436	1
		W4 vs. BL	0	1.0937	−2.1436	2.1436	1
		W5 vs. BL	1.3386	0.9439	−0.5114	3.1886	0.1562
		W6 vs. BL	1.1058	0.8062	−0.4742	2.6859	0.1702
Flatulence	Sequence 1 vs. 2		0	0.8711	−1.7074	1.7074	1
	Sequence 1	W1 vs. BL	1.0987	0.471	0.1756	2.0218	0.0197
		W2 vs. BL	1.2275	0.461	0.324	2.131	0.0078
		W3 vs. BL	−0.3793	0.8025	−1.9521	1.1936	0.6365
		W4 vs. BL	−1.0965	1.2459	−3.5384	1.3454	0.3788
		W5 vs. BL	−1.0965	1.2459	−3.5384	1.3454	0.3788
		W6 vs. BL	−1.0965	1.2459	−3.5384	1.3454	0.3788
	Sequence 2	W1 vs. BL	0	0.5227	−1.0244	1.0244	1
		W2 vs. BL	−0.0494	0.5296	−1.0874	0.9885	0.9256
		W3 vs. BL	−0.4911	0.4293	−1.3325	0.3502	0.2526
		W4 vs. BL	−0.0494	0.5296	−1.0874	0.9885	0.9256
		W5 vs. BL	1.5444	0.5457	0.4748	2.6141	0.0047
		W6 vs. BL	1.1939	0.541	0.1336	2.2542	0.0273
Heavy stomach	Sequence 1 vs. 2		0.1422	0.5364	−0.9091	1.1935	0.791
	Sequence 1	W1 vs. BL	−0.2612	0.2897	−0.829	0.3067	0.3673
		W2 vs. BL	−0.0935	0.3705	−0.8197	0.6326	0.8007
		W3 vs. BL	−0.0935	0.308	−0.6972	0.5102	0.7614
		W4 vs. BL	−0.2295	0.3383	−0.8925	0.4334	0.4974
		W5 vs. BL	−0.0587	0.3931	−0.8292	0.7117	0.8812
		W6 vs. BL	−0.0587	0.3928	−0.8286	0.7111	0.8811
	Sequence 2	W1 vs. BL	0.0167	0.3576	−0.6841	0.7176	0.9627
		W2 vs. BL	−0.215	0.3906	−0.9806	0.5507	0.5821
		W3 vs. BL	−0.1475	0.3687	−0.8702	0.5752	0.6891
		W4 vs. BL	−0.1475	0.3717	−0.8761	0.5811	0.6915
		W5 vs. BL	−0.2664	0.5159	−1.2776	0.7448	0.6056
		W6 vs. BL	−0.1131	0.5352	−1.1621	0.9358	0.8326
Borborygmus	Sequence 1 vs. 2		0.0635	0.6389	−1.1887	1.3157	0.9208
	Sequence 1	W1 vs. BL	1.337	0.4883	0.3799	2.2941	0.0062
		W2 vs. BL	1.4152	0.5307	0.3751	2.4553	0.0077
		W3 vs. BL	0	0.4311	−0.845	0.845	1
		W4 vs. BL	0.1847	0.456	−0.7092	1.0785	0.6856
		W5 vs. BL	−0.0619	0.4887	−1.0198	0.896	0.8993
		W6 vs. BL	0.2874	0.5223	−0.7362	1.311	0.5821
	Sequence 2	W1 vs. BL	0.1243	0.3335	−0.5293	0.7779	0.7094
		W2 vs. BL	−0.0606	0.2848	−0.6189	0.4977	0.8315
		W3 vs. BL	0.2951	0.2606	−0.2157	0.8058	0.2575
		W4 vs. BL	−0.0606	0.399	−0.8426	0.7214	0.8793
		W5 vs. BL	2.064	0.4595	1.1634	2.9647	<0.0001
		W6 vs. BL	1.7846	0.4922	0.8199	2.7494	0.0003

^aSequence 1: A1/A2 → A2

^bSequence 2: A2 → A1/A2

^cBaseline − specified visit

^dValues in bold are statistically significant at P < 0.05

SE standard error, BL baseline, W week