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. 2016 Apr 2;11:51. doi: 10.1186/s13014-016-0626-6

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© Mörén et al. 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Cross-validate score plot separating samples collected before and during treatment. The x-axis consits of the 10 patients included. The circles represent the time points before treatment and the triangles represents the time points during treatment. The OPLS-DA model consisted of 1 predicted and 1 orthogonal component and predicted 31.7 % of the response variation (Q2 = 0.317). The p-value based on ANOVA on the cross-validated OPLS-DA model is 0.01