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. 2016 Apr 2;11:51. doi: 10.1186/s13014-016-0626-6

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© Mörén et al. 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Cross-validated score plot based on metabolites in serum affected by treatment. The x-axis consists of the nine patients included. The circles represent the two time points before treatment started and the triangles the time points during treatment. The labels correspond to the sampling time point. 2* was calculated and used as a reference point in ITOT normalization of the treated samples. The OPLS-DA model consisted of 1 predicted and 1 orthogonal component and predicted 31.9 % of the response variation (Q2 = 0.319). The p-value based on ANOVA on the cross-validated OPLS-DA model is 0.006