Table 2.

Univariate and multivariate analyses of clinicopathological factors for overall survival in GC patients

Variables	Univariate analysis				Multivariate analysis
	HR	95 % CI		P value	HR	95 % CI		P value
		Lower	Upper			Lower	Upper
Gender	0.580	0.360	0.934	0.025	0.576	0.371	0.895	0.014
Age	1.682	1.071	2.641	0.024	1.634	1.066	2.505	0.024
Tumor location	0.972	0.736	1.285	0.844
Tumor size	1.045	0.636	1.717	0.862
Histologic type	0.890	0.686	1.155	0.380
Bormann classification	1.089	0.811	1.461	0.571
Differentiation grade	0.623	0.389	0.997	0.049	0.602	0.377	0.962	0.034
pT staging	0.742	0.274	2.007	0.557
pN staging	1.652	1.221	2.234	0.001	1.682	1.365	2.072	<0.001
pM staging	3.017	1.536	5.926	0.001	3.003	1.582	5.701	0.001
pTNM staging	1.272	0.488	3.315	0.622
SHH expression	1.776	1.119	2.820	0.015	1.734	1.109	2.713	0.016