Table 1.

Study investigations, treatments and follow-up summarize the full schedule of patient visits, treatment, imaging and assessments of adverse events

	Recruitment/baseline investigation	MR-guided HIFU treatment	Post-HIFU day 1	Post-HIFU day 7	Post-HIFU day 14	Palliative XRT/chemo	Post-HIFU day 30	Post-HIFU day 90
Physical examination	✓	✓	✓	✓	✓	soc	✓	✓
Blood work	✓					soc
MRI	✓	✓			✓	soc
Toxicity/SAE		✓	✓	✓	✓	soc	✓	✓
Pain and analgesic form		✓	✓	✓	✓	soc	✓	✓

Toxicity and SAE consists of anticipated adverse events screening, NCI CTCAE v4.03 toxicity score and SAE evaluating form when adverse events meet SAE criteria. Pain and analgesic: assessment consists of a visual analogue scale (VAS) and HIFU-related pain and analgesic form

soc standard of care, visits and assessments will follow regular institutional practice. XRT radiotherapy treatment, SAE serious adverse experience